Link between MS and oxidative stress documented in spinal fluid
This article was published December 2008
the link below should take you to the article --
J Neurol Sci. Author manuscript; available in PMC 2008 December 15.
Published in final edited form as:
J Neurol Sci. 2008 December 15; 275(1-2): 106–112.
Published online 2008 September 9. doi: 10.1016/j.jns.2008.07.032.
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Cerebrospinal fluid evidence of increased extra-mitochondrial glucose metabolism implicates mitochondrial dysfunction in multiple sclerosis disease progression
William T. Regenold,1 Pornima Phatak,1 Michael J. Makley,2 Roger D. Stone,3 and Mitchel A. Kling4
1University of Maryland School of Medicine, Department of Psychiatry, Division of Geriatric Psychiatry, and the Baltimore Veterans Affairs Medical Center, Research Service, Baltimore, MD 21201, USA
2University of Maryland School of Medicine, Department of Neurology, Comprehensive Multiple Sclerosis Center Baltimore, MD 21201, USA
3National Institute of Neurological Disorders and Stroke, Neuroimmunology Branch, Bethesda, MD, USA
4Wyeth Pharmaceuticals, Division of Clinical Translational Medicine. Formerly, National Institute of Mental Health, Clinical Neuroendocrinology Branch, Bethesda, MD, USA
This was published in the Journal of Neurological Sciences in December 2008. These authors talk about the evidence of mitochondrial dysfunction in those with progressive MS. Quoting from their abstract: "... the extra-mitochondrial glucose metabolism increases with impaired mitochondrial metabolism of glucose, these findings implicate mitochondrial dysfunction in the pathogenesis of MS disease progression. CSF metabolic profiling may be useful in clarifying the role of mitochondrial pathology in progression and in targeting and monitoring therapies for disease progression that aim to preserve or boost mitochondrial glucose metabolism."
This is yet another bit of evidence which supports my theory that mitochondrial health have a large role to play in progressive multiple sclerosis. It may not be the whole story - inflammation is probably a factor also. But fixing one's mitochondria is probably a very important long term strategy.